IMITREX Injection and are usually non-cardiac in origin. If you miss a dose of Imitrex tablets and you still have a headache, follow your doctor's dosing instructions. Contact your doctor immediately if you are unsure of what to do if you miss a dose. Do not take Imitrex tablets more often than prescribed. Do not take 2 doses at once. Endocrine and Metabolic: Infrequent was thirst.
You should take preventive medicine, unless your headache periods last less than 2 weeks. Cardiovascular: Infrequent were hypertension, hypotension, bradycardia, tachycardia, palpitations, pulsating sensations, various transient ECG changes nonspecific ST or T wave changes, prolongation of PR or QTc intervals, sinus arrhythmia, nonsustained ventricular premature beats, isolated junctional ectopic beats, atrial ectopic beats, delayed activation of the right ventricle and syncope. Rare were pallor, arrhythmia, abnormal pulse, vasodilatation, and Raynaud syndrome. You can take them as pills, injections, and skin patches.
There were insufficient data to assess the impact of race on efficacy. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody diarrhea; burning or aching in your feet or toes; burning, numbness, or tingling; constipation; diarrhea; fainting; feeling or heaviness or tightness in your leg muscles; fever; hearing problems; leg cramps; seizures; severe or persistent headache, dizziness, nausea, or vomiting; severe stomach pain; very cold or blue fingers or toes; vision changes or loss of vision; weight loss; wheezing.
IMITREX Injection also relieved photophobia, phonophobia sound sensitivity nausea, and vomiting associated with migraine attacks. Similar efficacy was seen when patients self-administered IMITREX Injection using an autoinjector. Respiratory: Bronchospasm in patients with and without a history of asthma. Heart attack and other heart problems.
Safety and effectiveness in pediatric patients have not been established. Imitrex Injection is not recommended for use in patients younger than 18 years of age. How long does it last? The treatment of migraine headaches with or without aura eg, flashing lights, wavy lines, dark spots. It may also be used for other conditions as determined by your doctor. Patients were instructed to treat a moderate to severe headache. Syringe Cartridge to the Cartridge Pack. After each use the Pen must be put back into the Carrying Case to reset the white Priming Rod before the next use. Now, I am drinking Pedialyte, in hopes of staving off the headache. The efficacy of Imitrex Tablets in the acute treatment of migraine headaches was demonstrated in 3, randomized, double-blind, placebo-controlled trials. It is unclear whether the nausea and vomiting is related to sumatriptan therapy or to the underlying condition. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Never reuse a syringe. Before injecting IMITREX, check with your doctor on acceptable injection sites and see the instructions inside the carton on discarding empty syringes and reloading an autoinjector device. Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Special Populations: Renal Impairment: The effect of renal impairment on the pharmacokinetics of sumatriptan has not been examined, but little clinical effect would be expected as sumatriptan is largely metabolized to an inactive substance. Following subcutaneous administration of sumatriptan, pain, redness, stinging, induration, swelling, contusion, subcutaneous bleeding, and, on rare occasions, lipoatrophy depression in the skin or lipohypertrophy enlargement or thickening of tissue have been reported.
Serious and sometimes fatal brain blood vessel problems like stroke have rarely happened with Imitrex spray. Contact your doctor at once if you have confusion, one-sided weakness, or speech or vision changes. The studies did not establish the efficacy of sumatriptan nasal spray compared to placebo in the treatment of migraine in adolescents. Adverse events observed in these clinical trials were similar in nature to those reported in clinical trials in adults. Instruct patients to read the Instructions for Use before starting therapy. Provide patients instruction on the proper use of Imitrex Injection if they are able to self-administer Imitrex Injection in medically unsupervised situations. Sumatriptan should not be used to treat a common tension headache or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches. IMITREX injections may have worse headaches medication overuse headache. Are you using inadequate contraception? This is truly the worst pain I have ever experienced, and I'm no stranger to pain. It is sharp, burning and frightening. And it happens immediately when I start to have a bowel movement, so I know for certain they are related. I just can't find any medical information about this, besides some other folks on message boards who seem to be experiencing the same symptoms. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. In patients who experience symptoms or signs suggestive of non-coronary vasospasm reaction following the use of any 5-HT 1 agonist, rule out a vasospastic reaction before receiving additional Imitrex Tablets. Oral administration of sumatriptan to pregnant rabbits during the period of organogenesis resulted in increased incidences of embryolethality and fetal cervicothoracic vascular and skeletal abnormalities. Intravenous administration of sumatriptan to pregnant rabbits during the period of organogenesis resulted in an increased incidence of embryolethality. IMITREX passes into your breast milk and may harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take IMITREX. You may have to try different drugs or doses. If you have already tried several medicines, your doctor may order tests such as an or to find out if a health problem is causing your headaches. An autoinjector device IMITREX STATdose Pen is available for use with 4-mg and 6-mg prefilled syringe cartridges. macrobid
The Pen is now ready to use. Sumatriptan may also be used for purposes not listed in this medication guide. What is the most important information I should know about sumatriptan? PREGNANCY and BREAST-FEEDING: It is not known if Imitrex spray can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Imitrex spray while you are pregnant. Imitrex spray is found in breast milk. If you are or will be breast-feeding while you use Imitrex spray, check with your doctor. Discuss any possible risks to your baby. Do not take more than 12 mg in a 24-hour period. This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case. Check with your pharmacist about how to dispose of unused medicine. Frequency not reported: Accommodation disorders, blindness, conjunctivitis, diplopia. The T max or amount absorbed was not significantly altered by either the site or technique of injection. sunh.info uroxatral
Mueller L, Gallagher RM, Ciervo CA "Vasospasm-induced myocardial infarction with sumatriptan. Researchers say triptans have become extremely popular in migraine treatment since they were introduced a decade ago. But many doctors do not understand why the drugs work well in some patients and not at all in others and why their effectiveness varies in individual patients from one migraine attack to the next. IMITREX Injection or Tablets. Serotonin syndrome is a possibly fatal syndrome that can be caused by Imitrex tablets. Your risk may be greater if you take Imitrex tablets with certain other medicines eg, SSRIs, SNRIs. Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms. Triptans narrow constrict vessels in the and relieve swelling. Triptans have other properties that may help treat symptoms. Use only if a clear diagnosis of migraine or cluster headache has been established. If a patient has no response to the first migraine or cluster headache attack treated with Imitrex Injection, reconsider the diagnosis before Imitrex Injection is administered to treat any subsequent attacks. To recall numbers, group them and then relate them to a date or story. The onset of symptoms generally occurs within minutes to hours of receiving a new or a greater dose of a serotoninergic medications. Triptans work best if you take them within 2 hours of the start of your pain. Eye: Accommodation disorders, blindness and low vision, conjunctivitis, disorders of sclera, external ocular muscle disorders, eye edema and swelling, eye hemorrhage, eye itching, eye pain, keratitis, mydriasis, and visual disturbances. The onset of symptoms usually occurs within minutes to hours of receiving a new or a greater dose of a serotonergic medication. Discontinue Imitrex Injection if serotonin syndrome is suspected. HT1 agonists. Discontinue IMITREX Injection if these disturbances occur. Corticosteroids. People who have hard-to-treat headaches, a history of headaches that keep coming back, or a severe type of migraine called “status migrainosus” can get relief by taking the steroid prednisone. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Eye: Ischemic optic neuropathy, retinal artery occlusion, retinal vein thrombosis, loss of vision.
Do not use if particulates and discolorations are noted. Imitrex Injection is a clear, colorless to pale yellow, sterile, nonpyrogenic solution for subcutaneous injection. Naproxen is known as a nonsteroidal anti-inflammatory drug NSAID. It is used to relieve pain. Sumatriptan belongs to a class of drugs called triptans. MAO-A inhibitors increase systemic exposure by 2-fold. USP in Water for Injection, USP. It is not known if Imitrex is safe and effective in children under 18 years of age. HT 1 agonists. Since visual disorders may be part of a migraine attack, a causal relationship between these events and the use of 5-HT 1 agonists have not been clearly established. Many people using this medication not have serious side effects. Pack for the 6-mg strength is blue as shown. Sumatriptan does not prevent future migraines or lessen how often you get migraine attacks. If you also take any ergotamine medication such as dihydroergotamine or other "triptan" drugs such as zolmitriptan, rizatriptan you will need to separate your sumatriptan dose from your dose of these other medications to lessen the chance of serious side effects. Ask your doctor how long you should wait between your doses of these drugs. The maximum single recommended adult dose of IMITREX Injection is 6 mg injected subcutaneously. Controlled clinical trials have failed to show that clear benefit is associated with the administration of a second 6-mg dose in patients who have failed to respond to a first injection. norethisterone
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Choose and Prepare the Injection Site. Refill Cartridge Packs are available. Nov. 7, 2003 -- The success or failure of treatment with the most commonly prescribed may depend on timing. GSK group of companies. 10000000124083 Rev. After a better Tuesday, the diarrhea returned on Wednesday. Lab tests, including heart function tests, may be performed while you use Imitrex tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. can you buy toprol in canada
Imitrex spray should be inhaled into the nose. Do not get it in your mouth or eyes. If you get it in your eyes, rinse right away with cool tap water. Contact your doctor or health care provider right away if any of these apply to you. IMITREX Injection is contraindicated in patients with hypersensitivity to sumatriptan or any of its components. IMITREX and certain other medicines can affect each other, causing serious side effects. Treatment should be started at the first sign of cluster headache, or associated symptoms such as nausea, vomiting, or photophobia. This drug should not be used prophylactically. Teratogenicity: Term fetuses from Dutch Stride rabbits treated during organogenesis with oral sumatriptan exhibited an increased incidence of cervicothoracic vascular and skeletal abnormalities. The functional significance of these abnormalities is not known. Imitrex spray. Be sure you understand how to use Imitrex spray. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. Treatment of migraine attacks with sumatriptan. the subcutaneous sumatriptan international study group. Respiratory: Infrequent was dyspnea. Rare were influenza, diseases of the lower respiratory tract, and hiccoughs. Remove device cover; remove disposable nosepiece from foil pouch and insert into the device until a click is heard; fully press and release white button to pierce capsule. If migraine returns after an initial dose of subcutaneous injection, additional oral doses may be given up to 100 mg orally per day, with at least a 2 hour interval between tablet doses.
You don't want to take your medicine too often, since it may stop working or cause more intense and more frequent "rebound headaches. Check your pressure regularly and tell your doctor if the results are high. IMITREX STAT dose System. There may be new information. Imitrex. Such reactions can be life threatening or fatal. In general, anaphylactic reactions to drugs are more likely to occur in individuals with a history of sensitivity to multiple allergens. Imitrex Tablets are contraindicated in patients with a history of hypersensitivity reaction to Imitrex. MacLean MR, Smith GC, Templeton AG "Adverse reactions associated with sumatriptan. cetirizine order now mastercard canada
This information should not be used to decide whether or not to take Imitrex spray or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Imitrex spray. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Imitrex spray. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Imitrex spray. Respiratory Rate: Experience gained during the clinical development of sumatriptan as a treatment for migraine failed to detect an effect of the drug on respiratory rate. Dose selection for the older patient should be cautious, generally starting at the lower end of the dosing range due to a greater frequency of hepatic, renal, cardiac impairment as well as presence of concomitant disease or drug therapy. Do not discard the auto-injector. You may use it again with refills of the prefilled syringes. However, if you are using a one-time use auto-injector, discard the auto-injector after use. If you are unsure if your auto-injector can be re-used, ask your pharmacist. Keep all medicines away from children and pets. Discontinue IMITREX Injection if a cerebrovascular event occurs. The systematic approach described above is intended to reduce the likelihood that patients with unrecognized cardiovascular disease will be inadvertently exposed to sumatriptan. Remove the nozzle from your nostril. Keep your head level for 10 to 20 seconds while gently breathing in through your nose and out through your mouth. Do NOT breathe in deeply. If your doctor decides to stop your treatment, do not keep any leftover medicine unless your doctor tells you to. Throw away your medicine as instructed. off brand nimotop
Since sumatriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using sumatriptan. Write your daily activities on a calendar or daily planner, and keep it in a place where you can see it easily. Two studies published in the Nov. 7 advance online edition of the Annals of Neurology suggest that the success of migraine treatment with triptans is related to the skin sensitivity symptom commonly found in migraine sufferers. This symptom, known as cutaneous allodynia, occurs in about three-fourths of migraine suffers and frequently affects the skin of the face and neck, making even mundane activities like brushing one's or shaving extremely painful. Different brands of this have differentstorage needs. Defects in the corneal epithelium were noted in a 60-week study. Earlier examinations for these toxicities were not conducted and no-effect doses were not established; however, the relative plasma exposure at the lowest dose tested was approximately 3 times the human exposure after a 6-mg subcutaneous dose. Table 2 below, onset of relief began as early as 10 minutes following a 6-mg IMITREX Injection. Smaller doses of sumatriptan may also prove effective, although the proportion of patients obtaining adequate relief is decreased and the latency to that relief is greater. Other Events Observed in Association With the Administration of IMITREX Injection: In the paragraphs that follow, the frequencies of less commonly reported adverse clinical events are presented. Because the reports include events observed in open and uncontrolled studies, the role of IMITREX Injection in their causation cannot be reliably determined. Furthermore, variability associated with adverse event reporting, the terminology used to describe adverse events, etc. Heart Rate: Transient increases in blood pressure observed in some patients in clinical studies carried out during sumatriptan's development as a treatment for migraine were not accompanied by any clinically significant changes in heart rate.
IMITREX. These reports include reactions similar in nature to those reported rarely in adults, including stroke, visual loss, and death. A myocardial infarction has been reported in a 14-year-old male following the use of oral IMITREX; clinical signs occurred within 1 day of drug administration. Clinical data to determine the frequency of serious adverse reactions in pediatric patients who might receive subcutaneous, oral, or intranasal IMITREX are not presently available. Product Information. Alsuma SUMAtriptan. If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household spoon. Some liquid products need to be shaken before each dose. Some products that contain need to be placed under the and held there before swallowing. Follow label directions carefully to get the most benefit. Studies show caffeine makes pain relievers more effective and may help your body absorb other drugs, Calhoun says. But it has some drawbacks. Studies 2 and 3 the onset of relief was less than 10 minutes. Headache relief, as defined by a reduction in pain from severe or moderately severe to mild or no headache, was achieved in 70% of the patients within 1 hour of a single 6-mg subcutaneous dose of Imitrex Injection. Approximately 82% and 65% of patients treated with IMITREX 6 mg had headache relief and were pain free within 2 hours, respectively. price atopex medication
For the treatment of cluster headache, the efficacy of lower doses has not been established. IMITREX are not presently available. This Patient Information leaflet summarizes the most important information about Imitrex. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about Imitrex that is written for healthcare professionals. Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT 1 agonists. Discontinue Imitrex Injection if these disturbances occur. Imitrex Injection is contraindicated in patients with Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders. Review all your prescription and nonprescription and dosages with your doctor or pharmacist. Many medicines, by themselves or in combination with other medicines, can cause mental confusion. Also, confusion may occur when medicines interact in your body. If you see several doctors, make sure that they all know what other medicines you are taking. Have all of your filled at the same pharmacy. Ask your doctor or pharmacist whether the combination of your medicines could cause problems. Side Effects List Imitrex side effects by likelihood and severity. Pregnancy Category C: There are no adequate and well-controlled trials in pregnant women. In developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality. When administered by the intravenous route to pregnant rabbits, sumatriptan was embryolethal. Imitrex Tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Some people may have feelings of tingling, heat, flushing redness of face lasting a short time heaviness or pressure after treatment with IMITREX Injection. A few people may feel drowsy, dizzy, tired, or sick. Tell your doctor of these symptoms at your next visit. You'll get one to three of these headaches a day. IMITREX Injection, call your doctor immediately. F. Protect from light. Nasal spray: A 10 mg intranasal dose may be administered as 5 mg in each nostril. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see section. This year, I finally went to a doctor because I was tired of my migraines controlling my life. She first gave me the sumatriptan pills 10 mg at first, then 20 mg but it didn't stop the vomiting. Therefore, I couldn't keep the medicine down long enough for it to start working. So, she prescribed me the nasal spray. clomiphene
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Push the Blue Button. Imitrex Injection is a prescription medicine used to treat acute migraine headaches with or without aura and acute cluster headaches in adults who have been diagnosed with migraine or cluster headaches. Do not use IMITREX Injection if you are pregnant, think you might be pregnant, are trying to become pregnant, or are not using adequate contraception, unless you have discussed this with your doctor.
IMITREX Injection is contraindicated. Cluster headaches are more common in people who smoke or are heavy drinkers. During a cluster period, you'll be more sensitive to alcohol and nicotine -- just a bit of alcohol can trigger a headache. But drinking won't trigger one during headache-free periods. Use: For the acute treatment of cluster headache. The figure shows the probability over time of obtaining headache response no or mild pain following treatment with oral sumatriptan. The averages displayed are based on pooled data from the 3 clinical controlled trials providing evidence of efficacy.
Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. Before treating headaches in patients not previously diagnosed with migraine or cluster headache or in patients who present with atypical symptoms, exclude other potentially serious neurological conditions. Imitrex Injection is contraindicated in patients with a history of stroke or TIA. GSK group of companies.
These trials did not establish the efficacy of oral Imitrex compared with placebo in the treatment of migraine in adolescents. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. If your symptoms are only partly relieved or your returns, 2 hours after the injection you may switch to sumatriptan taken by instead of using a second injection. After the initial injection you may take sumatriptan by every 2 hours if needed to a maximum of 100 milligrams of tablets in a 24-hour period. IMITREX. Such reactions can be life threatening or fatal.